Effects of an Opioid Free/Sparing Care Pathway for Patients Undergoing Obesity Surgery

• Status: Recruiting
• Trial end date: 2024-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The opioid consumption has exploded in the western world 1, and for some patient populations such as obese patients, patients with sleep apnoea or patients undergoing cancer treatment, opioid-sparing/ opioid-free strategies could have positive effects on outcomes. Studies suggest that opioids could have opioid-induced immunosuppression, induce chronic post-operative pain syndrome and hyperalgesia in addition to the more well-known side effects such as respiratory depression, nausea, bladder, and bowel dysfunction. Hence, new studies are needed on the impact of person-centered care programs that combine pharmaceutical and non-pharmaceutical strategies to reduce the adverse short and long-term effects of opioid therapy.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Göteborg University
• Treatments: Analgesics, Opioid; Anesthetics; Desflurane; Dexmedetomidine; Esketamine; Isoflurane; Lidocaine; Oxycodone; Propofol; Remifentanil

Criteria

Inclusion Criteria:

-Patients ≥18 years planned to undergo laparoscopic obesity surgery (GBP alt Sleeve surgery) at the selected site.

Exclusion Criteria:

• ASA> III

• Cardiovascular disease with bradycardia (<50 bpm)

• Serious liver disease failure

• Insufficient knowledge of the Swedish language

• Serious untreated psychiatric disease

• Neurocognitive dysfunction

• Pregnancy

• Women of childbearing age without contraception

• Malignant disease with expected short survival

• Patients treated with opioids for chronic pain

• Substance abuse

• Hypersensitivity to Oxycodone, Esketamine, Dexmedetomidine, and Lidocaine

• Pacemaker or ICD

• Inability to fill in questionnaires

• Decline participation,