Effects of the Anti-HIV Pill Truvada on Gene Transcription in the Gastrointestinal Tract of HIV-uninfected Individuals
Status:
Completed
Trial end date:
2017-12-01
Target enrollment:
Participant gender:
Summary
As explained in detail in a recently published hypothesis article (Hladik F. A new hypothesis
on HIV cure. F1000Research, 4:77 (2015)), the investigators hypothesize that NRTI drugs may
reduce the likelihood of HIV eradication by promoting the survival of cells with integrated
provirus. In this study, the investigators will test whether daily oral use of two NTRI
drugs, tenofovir and emtricitabine (Truvada Pill), induces changes in the upper and lower gut
mucosa that are congruent with supporting this hypothesis.
Phase:
N/A
Details
Lead Sponsor:
University of Washington
Treatments:
Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination