Effects of the D3 Antagonist GSK598809 on Food Reward and Reinforcement

• Status: Completed
• Trial end date: 2010-04-26
• Target enrollment: 0
• Participant gender: All

Summary

This novel compound is a new experimental treatment that may help people to stop compulsive overeating. Compulsive overeating or binge eating is one of the main reasons why people are overweight or obese. Recent research has shown that some kinds of overeating may be linked to a brain chemical called dopamine. There is some evidence that blocking the action of this chemical in animals can reduce food intake, particularly of foods that are high in fat and sugar. The purpose of this study is to find out if this compound (which blocks the effects of dopamine) has the same effect in overweight or obese people, as it does in animals.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: GlaxoSmithKline

Criteria

Inclusion Criteria:

• generally healthy

• right handed

• binge eating episode

• use appropriate contraception method

• willing to see a dietician

• overweight or obese (BMI 27 - 40 kg/m2)

Exclusion Criteria:

• pregnant or breast feeding female

• recent weight loss or gain

• recent use of weight loss drugs

• surgery for obesity

• abuse alcohol or drugs

• cannot do MRI scans

• smokers

• certain emotional problems being treated with medications

• medical, surgical or neuropsychiatric illness

• ECG abnormality

• sudden unexplained death or syncope in first degree relatives