Efficacies of Antimicrobial Susceptibility-Guided Versus Empirical Therapy for Rescue Treatment of Helicobacter Pylori Infection

• Status: Completed
• Trial end date: 2019-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to assess efficacy of 14-day antimicrobial susceptibility test guided quadruple therapy for the rescue treatment of Helicobacter pylori infection, then comparing it with 14-day empirical therapy according to personal medication history.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Shandong University
• Treatments: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Antibiotics, Antitubercular; Bismuth; Clarithromycin; Furazolidone; Levofloxacin; Metronidazole; Ofloxacin; Pectin; Proton Pump Inhibitors; Tetracycline; Tinidazole

Criteria

Inclusion Criteria:

• Patients aged 18-70 with persistent Helicobacter pylori infection.

• Patients with previous Helicobacter pylori eradication therapy for one or two times.

Exclusion Criteria:

• Patients unable or unwilling to receive gastroscopy.

• Patients treated with Histamine-receptor antagonist, proton pump inhibitor, bismuth and antibiotics in the previous 4 weeks.

• Patients with gastrectomy, acute gastrointestinal bleeding and advanced gastric cancer.

• Patients with known or suspected allergy to study medications.

• Currently pregnant or lactating.

• Inability to provide informed consent and other situations that could interfere with the examination or therapeutic protocol.