Efficacies of Tetracycline-levofloxacin, Standard Bismuth, Amoxicillin-levofloxacin Quadruple Therapy for H.p

• Status: Recruiting
• Trial end date: 2024-12-31
• Target enrollment: 0
• Participant gender: All

Summary

1. Compare the efficacy of "Tetracycline combined with levofloxacin quadruple therapy", "standard tincture quadruple therapy" and "amoxicillin combined with levofloxacin quadruple therapy" on the second line of Helicobacter pylori sterilization.

2. To investigate the drug resistance of Helicobacter pylori and the host genotypes of CYP2C19 and IL-1B-511 on the sterilizing effect of three second-line Helicobacter pylori.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Kaohsiung Medical University
• Treatments: Amoxicillin; Esomeprazole; Levofloxacin; Metronidazole; Ofloxacin; Tetracycline

Criteria

Inclusion Criteria:

1. at least 20 years old

2. subject was failure for the first line therapy of Helicobacter pylori

Exclusion Criteria:

1. Those who are allergic to the drugs used in this study

2. Those who have had a stomach surgery

3. Those who have antibiotics within four weeks of treatment

4. Those who have severe cirrhosis, uremia or malignancy

5. Those who are a pregnant woman or a woman who breastfeeds