Efficacies of Two Bismuth Quadruple Therapies in the Second-line Treatment of H Pylori Infection

• Status: Recruiting
• Trial end date: 2021-12-31
• Target enrollment: 0
• Participant gender: All

Summary

From the profiles of antibiotic susceptibility data following eradication therapy, tetracycline, amoxicillin and levofloxacin are all good candidates of antibiotics used in the rescue treatment.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ping-I (William) Hsu, M.D.
• Treatments: Amoxicillin; Bismuth; Esomeprazole; Levofloxacin; Ofloxacin; Tetracycline

Criteria

Inclusion Criteria:

• Consecutive H pylori-infected outpatients, at least 20 years of age with failure of first-line eradication treatments (standard triple, non-bismuth quadruple and bismuth quadruple therapies)

Exclusion Criteria:

• previous allergic reactions to the study medications,

• history of gastrectomy,

• use of antibiotics within the previous 4 weeks,

• pregnant or lactating women,

• coexistence of serious concomitant illness (for example, decompensated liver cirrhosis, uremia, and malignancy).