Efficacy Of Bupropion For Attention Deficit Hyperactivity Disorder (ADHD) In Adults

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The investigators propose to conduct an open study to evaluate the efficacy and tolerability of Bupropion SR using clinically relevant doses in ADHD adults with a recent history of or current substance use disorders. We hypothesize that Bupropion SR will be effective in treating ADHD in this population.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Massachusetts General Hospital
• Treatments: Bupropion

Criteria

Inclusion Criteria:

• Male and female outpatients 18 years old or older, up to 60 years old.

• Patients with the diagnosis of Attention Deficit Hyperactivity Disorder (ADHD), by DSM-IV, as manifested in clinical evaluation and confirmed by structured interview.

• Patients within the past 6 months known to abuse or to be dependent on alcohol or any drug (nicotine addiction not included)

Exclusion Criteria:

• Any clinically unstable medical condition

• Clinically significant abnormal baseline laboratory values

• Mental retardation (I.Q. <75) or Organic brain disorders

• Seizure disorder

• Patients with a history or an eating disorder including anorexia or bulimia nervosa

• Pregnant or nursing females

• Patients with current bipolar disorder

• Psychotic disorder of any type

• Patients on psychotropics known to treat ADHD (i.e. stimulants, tricyclics)

• Patients receiving psychotherapy known to treat ADHD (i.e. cognitive or cognitive/behavioral psychotherapy)

• Patients demonstrating active withdrawal from substance abuse