Efficacy, Safety and Re-occurrence of Pneumothorax and Hydro-pneumothorax With Talc and Pyodine Pleurodesis
Status:
Unknown status
Trial end date:
2019-12-01
Target enrollment:
Participant gender:
Summary
Abstract:
INTRODUCTION:
Pneumothorax and hydro-pneumothorax are the most common thoracic injuries and poses a risk of
serious morbidity.To prevent the lung from collapsing in such condition, pleurodesis
procedure is performed either with surgical pleurodesis,or chemical pleurodesis which adheres
outside the lung to the inside chest cavity. The common chemicals that are used are
bleomycin, tetracycline, minocycline, slurry of talc and povidoneiodine.
In developed countries, the most common chemical agent used is talc, tetracycline derivatives
and bleomycin. However, its clinical results depend on the level of collapse of the lung on
the affected side.Internationally, for spontaneous pneumothoraces, talc is the best chemical
for pleurodesis procedure which is insufflation through thoracoscopy. However its safety is
debateable especially in acute respiratory disease after its administrationwhich made it null
and vide consequently. Secondly, in developing countries,medical grade talc availability and
affordability remains a constraint. The other suitable chemical is Iodopovidone which is
inexpensive and widely used as topical antiseptic in many countries. It also hasshown a safe
and effective chemical agent for pleurodesis procedure.
OBJECTIVES:
To determine the efficacy, safety and reoccurrence rate of in pneumothorax and
hydro-pneumothorax patients after procedure with talc and pyodine pleurodesis: A comparative
study.
MATERIALS AND METHOD:
On the basis of inclusion criteria, the selected 104 patients will be grouped (talc and
pyodine) through Non probability, purposive sampling method. In each group 52 willing
participants will be included without considering the size of pneumothorax. Six readings of
each individual participant will be taken (3 before procedure and 3 after procedure for each
group) for pulse and respiratory rate, fever, and total counts of leukocyte. Pain will be
assessed on analogue scale. The readings will be taken with 8 hours gap apart. Re-occurrence
will be determined after 6 months period of the procedure along with complications if any.
The results of both groups will be compared for Efficacy, Safety and Re-occurrence of
Pneumothorax and Hydro-pneumothorax.
KEYWORDS:
Pyodine pleurodesis, Talc, hydro-pneumothorax, iodopovidone, pleural effusion, pneumothorax,
malignant/prevention & control; Pleurodesis/methods; Recurrence