Efficacy Study of Anakinra, Pentoxifylline, and Zinc Compared to Methylprednisolone in Severe Acute Alcoholic Hepatitis
Status:
Completed
Trial end date:
2018-10-01
Target enrollment:
Participant gender:
Summary
This study will compare two different treatments of acute alcoholic hepatitis. The current
standard of care is treatment with corticosteroids (methylprednisolone). This will be
compared to treatment with anakinra, pentoxifylline, plus zinc sulfate. The participants will
be treated and followed for 6 months and the two treatment groups will be compared for
differences in death rates and laboratory tests that measure liver and gut function.
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
Mack Mitchell
Collaborators:
National Institute on Alcohol Abuse and Alcoholism (NIAAA) The Cleveland Clinic University of Louisville University of Massachusetts, Worcester