Efficacy Study of Atorvastatin to Treat Variant Angina

• Status: Unknown status
• Trial end date: 2010-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The objective of this study is to evaluate effect of statin treatment for vasospastic angina.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Samsung Medical Center
• Treatments: Atorvastatin; Atorvastatin Calcium

Criteria

Inclusion Criteria:

• Vasospastic angina or spontaneous spasm during coronary angiography (Vasospastic angina is defined as Thrombolysis In Myocardial Infarction (TIMI) flow grade 0-2 noted in intracoronary ergonovine provocation test and development of chest pain or EKG change; Spontaneous spasm is defined as TIMI flow grade 0-2 of coronary artery without ergonovine injection)

• Normal or insignificant lesion (diameter stenosis <50%) on coronary angiography

Exclusion Criteria:

• Elevated liver enzyme: serum aspartate aminotransferase or alanine aminotransferase concentrations more than 3 times the upper limit of normal

• Significant lesion( diameter stenosis ≥50%) documented in coronary angiography

• Pregnancy

• Prior percutaneous coronary intervention or coronary artery bypass surgery

• Previous statin use

• Impaired renal function with serum creatinine ≥ 2.0 mg/dl

• Severe left ventricular dysfunction ( LVEF ≤ 30% on echocardiography)

• Myopathy