Efficacy Study of Different Analgesic Options in Kidney Stone Pain Management

• Status: Completed
• Trial end date: 2015-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Abdominal pain is one of the most common presentations to an emergency department (ED). Among patients presenting with abdominal pain, a common diagnosis in the Middle East is renal colic (urolithiasis or Kidney stones). As the patients with renal colic writhe around in agonizing pain, the first priority in an ED from a patient's perspective is fast and safe analgesia and to be pain free as early as possible. There are variations in physician preference to choose initial analgesic drug for managing such pain. Commonly used drugs are:

• Opioids such as Morphine or Fentanyl

• Non steroidal drugs such as Diclofenac, Ketorolac or Brufen

• and Paracetamol intravenous injection.

A robust evidence in comparison of diclofenac versus morphine and paracetamol is lacking. This study is design to obtain data on efficacy of these three drugs within 30 minutes in a non inferiority trail.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hamad Medical Corporation
• Treatments: Acetaminophen; Diclofenac; Morphine; Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• Age >=18 years and < 65 years

• Acute onset, one side flank or loin pain, with or without radiation to groin or genital areas.

• Pain intensity on NRS more than or equal to 4. (Moderate to Severe Pain)

• Diagnosis confirmed by non contrast CT KUB within the ED visit.

Exclusion Criteria:

• Traumatic flank pain

• Pregnancy

• Known renal failure or impairment

• Known allergy to morphine, diclofenac or paracetamol

• Bronchial asthma

• Previously enrolled in the study.

• Use of any analgesia in last 6 hour.