Efficacy Study of Pneumococcal Vaccination in Crohn's Disease
Status:
Completed
Trial end date:
2013-06-01
Target enrollment:
Participant gender:
Summary
A growing number of patients with Crohn's disease are treated with immunosuppressive agents,
such as anti-tumor necrosis factor blockers and immunomodulators. Several recent studies have
indicated that immunosuppressive treatment may impair the immunological response to
pneumococcal vaccination in patients with inflammatory bowel disease (Crohn's disease and
Ulcerative colitis). One of weaknesses in the previous studies did not focus on specific
disease, such as Crohn's disease. In addition, predictive factors affecting impaired response
following pneumococcal vaccination have not clearly evaluated in patients with Crohn's
disease. In this study, patients with Crohn's disease will be assessed for serological
response to pneumococcal vaccination. Further, potential predictive factors that impact on
vaccination outcomes and adverse events related to vaccination will be evaluated.
Phase:
Phase 4
Details
Lead Sponsor:
Kyunghee University Medical Center
Collaborators:
Asan Medical Center Chung-Ang University Hosptial, Chung-Ang University College of Medicine Ewha Womans University Inje University Keimyung University Dongsan Medical Center Konkuk University Hospital Korea University Kosin University Gospel Hospital Seoul National University Hospital Severance Hospital Soonchunhyang University Hospital The Catholic University of Korea Wonju Severance Christian Hospital Wonkwang University