Efficacy & Safety Study of Nonracemic Methadone for the Relief of Chronic Peripheral Neuropathic Pain
Status:
Completed
Trial end date:
2014-12-01
Target enrollment:
Participant gender:
Summary
There is a growing evidence that the d-isomer of methadone is effective in treating
neuropathic pain while the l-isomer of methadone is the only effective isomer of methadone
for treating somatic pain. This study will examine a combination of different amounts of the
d- and l-isomers of methadone specifically tailored to the chronic peripheral neuropathic
pain. Non-racemic mixture of methadone isomers will be tested in this pilot efficacy and
safety study.
This study will evaluate effect of the three doses of the non-racemic mixture of methadone
hydrochloride patients with chronic peripheral neuropathic pain compared with a placebo. The
study will also examine the minimally effective and maximally tolerated doses of the
non-racemic mixture of methadone. Finally, the safety and tolerability of the non-racemic
methadone therapy will be evaluated.