Efficacy and Safety Study of Peginterferon Alfa-2b in Chinese Chronic Hepatitis C Patients

• Status: Completed
• Trial end date: 2014-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate the efficacy and safety of Peginterferon alfa-2b (40KD, Y shape, the followings will refer as Ypeginterferon alfa-2b for short), at a dose of 180μg/week, in combination with Ribavirin in Chinese chronic hepatitis C patients. The study will first group patients into two sub-study, genotype 2/3 and non-genotype 2/3, depending on the HCV genotype that infected. In the genotype 2/3 sub-study about 219 patients will be enrolled, and eligible patients are randomized at 2:1 ratio into Ypeginterferon alfa-2b group or active control group (Pegasys), receiving 24 weeks of interferon therapy and oral daily Ribavirin at a dose of 800mg/d. In the non-genotype 2/3 sub-study about 507 patients will be enrolled, and eligible patients are randomized at 2:1 ratio into Ypeginterferon alfa-2b group or active control group (Pegasys), receiving 48 weeks of interferon therapy and oral daily Ribavirin 1000-1200mg/day , basing on body weight. All patients will be followed for 24 weeks after the end of therapy.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Xiamen Amoytop Biotech Co., Ltd.
• Treatments: Interferon-alpha; Peginterferon alfa-2a; Peginterferon alfa-2b; Ribavirin

Criteria

Inclusion Criteria:

• 18~65 years

• Hepatitis virus C chronic infection evidences: HCV RNA or anti-HCV positive>6 months,or other evidences supporting diagnosis of chronic hepatitis C infection

• HCV RNA≥2000IU/mL, anti-HCV positive at screening

• Pregnancy tests for female patients must be negative. All patients must take effective contraception measures during the study period

• Signed informed consent

Exclusion Criteria:

• Pregnant or lactating women

• Mental or psychology disorder

• ANC<1500/mm3, or PLT<90,000/mm3, or Hb- Received interferon treatment within the previous 6 months or shown no-response to previous interferon treatment

• Co-infection with HIV, HAV, HBV, HEV

• Evidence of hepatic decompensation (e.g: Child Plug≥B, prothrombin time prolonged more than 3 seconds, TBil>2ULN, Alb<35g/L)

• Hepatocarcinoma or suffering from any other malignant tumor

• Not well controlled endocrine diseases(e.g:thyroid disfunction, mellitus mellitus)

• Significant function damage in any major organs (e.g: heart, lung, kidney)

• Involved in other investigation within the previous 3 months

• Other conditions which in the opinion of the investigator precluding enrollment into the study (e.g: poor compliance)