Overview
Efficacy and Safety Study of Prucalopride for the Treatment of Patients With Chronic Constipation
Status:
Completed
Completed
Trial end date:
1999-05-01
1999-05-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
The purpose of this study is to determine whether prucalopride is safe and effective in the treatment of chronic constipation Hypothesis: Prucalopride 2 mg and 4 mg given once daily for 12 weeks is superior to placebo for the treatment of patients with chronic constipation and is well tolerated in those patientsPhase:
Phase 3Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
MovetisTreatments:
Prucalopride
Criteria
Inclusion Criteria:1. Male and non-pregnant, non breast-feeding female outpatients at least 18 years of age
(no upper age limit).
2. History of constipation; the subject reports, ona average,two of fewer spontaneous
bowel movements per week that result in a feeling of complete evacuation and one or
more of the following for at least 6 months before the selection visit:
1. very hard (little balls) and/or hard stools at least a quarter of the stools
2. sensation of incomplete evacuation following at least a quarter of the stools
3. straining at defecation at least a quarter of the time. The above criteria are
only applicable for spontaneous bowel movements, i.e., not preceded within a
period of 24 hours by the intake of a laxative agent or by the use of an enema.
Subjects who never have spontaneous bowel movements are considered to be constipated and
are eligible for the trial.
Exclusion Criteria:
1. Subjects in whom constipation is thought to be drug-induced, or subjects using any
disallowed medication.
2. Subjects suffering from endocrine disorders, metabolic disorders or neurologic
disorders.
3. Subjects with a megacolon/megarectum or a diagnosis of pseudo-obstruction.
4. Constipation as a result of surgery.
5. Known or suspected organic disorders of the large bowel, i.e. obstruction, carcinoma,
or inflammatory bowel disease.
6. Subjects with severe and clinically uncontrolled cardiovascular, liver, or lung
disease, neurologic or psychiatric disorders (including active alcohol or drug abuse),
cancer or AIDS, and other gastrointestinal or endocrine disorders.
7. Subjects with impaired renal function.
8. Subjects with clinically significant abnormalities of haematology, urinalysis, or
blood chemistry.
9. Females of child-bearing potential without adequate contraceptive protection during
the trial.