Efficacy and Safety Study of Short-term Antibiotic for Pyelonephritis in Women
Status:
Completed
Trial end date:
2013-12-01
Target enrollment:
Participant gender:
Summary
Urinary tract community infections are one of very frequent reason consultation and
prescription. Urinary tract represents the second site of bacterial community infection after
the respiratory system. The management of the acute uncomplicated pyelonephritis was simply
codified in the past recommendations of the French Agency for Safety Health Products
(AFSSAPS) in 2008. Treatment is based on two main families of antibiotics, fluoroquinolones
with 7 days treatment and 3rd generation cephalosporins with 10 to 14 days treatment.
The practice of a short treatment with ceftriaxone intra venous relayed by cefixime orally
provides a simplified treatment for patients, a reduced use of fluoroquinolones and a
probable decrease in correlation with the emergence of fluoroquinolones resistance, and
finally, a decrease in the cost of treatment of acute uncomplicated pyelonephritis.