Efficacy and Safety of 1612 Capsules in aMnestic Mild Cognitive Impairment

• Status: Withdrawn
• Trial end date: 2018-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This study is a 52-weeks, multicenter, randomized, double-blind, placebo controlled, parallel trial which will be carried out in 15 centers around China. The study population includes amnestic mild cognitive impairment patients (planned a total of 240) aged 55-85 in both gender. Participants will be randomly allocated to 1612 capsules (1.14g per time, 3 times per day) or placebo for a 52-weeks double-blind treatment period. The primary outcome measure is change from baseline in the Alzheimer's Disease Assessment Scale- Cognition Subscale (ADAS-cog) and rate of conversion to dementia. The secondary outcomes are changes from baseline in the Mini-Mental State Examination (MMSE), Delayed Story Recall test (DSR), Alzheimer's Disease Cooperative Study/Activities of Daily Living scale adapted for MCI patients (ADCS/MCI/ADL24). Safety is being assessed by observing side effects and adverse reaction during the entire treatment period. Statistical analysis will be conducted according to per-protocol population and intend-to-treat population and the safety will be analyzed in safety set.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Dongzhimen Hospital, Beijing

Criteria

Inclusion Criteria:

Patients should be enrolled if they met the following criteria[14]:

1. cognitive complaints from the patients or their families;

2. objective evidence for memory impairment, delayed story recall test(DSR)<12.6(age50-64 less than15.5,65-74less than 12.5,older 75 less than10);

3. normal general cognitive function, with Mini-Mental State Examination (MMSE) score of between 24 and 30 (including 30);

4. preservation of activities of daily living, with Alzheimer's Disease Cooperative Study/Activities of Daily Living scale adapted for MCI patients (ADCS/MCI/ADL24) score between 38 and 52;

5. cognitive disorders as evidenced by clinical evaluation, with clinical dementia rating scale=0.5,memory domain = 0.5;

6. absence of dementia, not sufficiently impaired cognitively and functionally to meet DSM-IV criteria,

7. enough vision and hearing to accomplishment neuropsychological test;

8. capability to read words and write simple sentence;

9. capability and willingness to give informed consent and to comply with the study procedures.

Exclusion Criteria:

The patients would be ineligible if they had the following conditions:

1. non amnestic Mild cognitive impairment;

2. meeting the diagnostic criteria for dementia;

3. cognitive impairment resulting from conditions such as acute cerebral trauma, cerebral damage due to a lack of oxygen, epilepsy vitamin deficiency, infections such as meningitis or AIDS, significant endocrine or metabolic disease, mental retardation, or a brain tumor ,or drug abuse or alcohol abuse

4. having significant psychiatric disease, depression, the Hamilton depression scale >12; CT or MRI scan showed central nervous system infections Infarction or focal lesions within 12 months，the Hachinski Ischemic Scale (HIS)>4;

5. combined following disease: diabetes; poor controlled hypertension or severe arrhythmias; or suffered from heart infarction within 3 months; severe asthma or COPD; severe indigestion; gastrointestinal tract obstruction; gastroduodenal ulcer;

6. used cholinesterase inhibitors or memantine within 1 month;

7. history of hypersensitivity to the treatment drugs;

8. concomitant drugs with the potential to interfere with cognition;

9. administration of other investigational drugs; severe impairment of the functions of the kidney or liver;

10. vegetarians or contraindications for animal innards.