Efficacy and Safety of 3% Hypertonic Saline Inhalation (24h vs 72h) to Treat Acute Bronchiolitis in Hospitalized Infants

• Status: Completed
• Trial end date: 2016-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Efficacy/Safety of 3% hypertonic saline inhalation (24H vs 72H) to treat acute bronchiolitis in infants.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Grenoble
• Collaborator: AGIR à Dom

Criteria

Inclusion Criteria:

• 1st or 2nd episode of acute bronchiolitis, defined by respiratory symptoms episode with initial rhinitis, then cough, then one of the following symptoms : wheezing, crackling, respiratory distress

• Winter epidemic period from November, the 15th, to March the 15th

• Age < 12 months

• Admission Wang score included between 4 and 8

• Infant hospitalized for gravity clinical criteria of severity

• Nebulized 3 % hypertonic saline treatment since less than 24 hours

• Infant with social security card coverage

• Free consent of at least one of the parental authority holder

Exclusion Criteria:

• Pulmonary, cardiac or neurologic chronic underlying disease

• Prematurity < 32 GW

• Asthma (3rd episode or more)

• Admission oxygen saturation level < 85 %, Wang score ≥ 9