Efficacy and Safety of Adalimumab 80 mg Every Other Week With Methotrexate
Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
In Japan, as well as in other countries, the dose of adalimumab (ADA) is limited to 40 mg
every other week when used in combination with methotrexate (MTX) for patients with
rheumatoid arthritis (RA). However, ADA 80 mg with MTX may be required for some RA patients,
especially for those with high disease activity. Therefore, we tried to increase the ADA dose
to 80 mg every other week with concomitant MTX, only if the disease activity did not decrease
below moderate activity defined by DAS28 < 3.2. The primary endpoint was the rate of patients
who achieved disease remission (DAS28 < 2.6) at 30 weeks with this predifined treatment
strategy.