Efficacy and Safety of Articaine and Lidocaine in Extraction of Wisdom Teeth of Upper and Lower Jaws

• Status: Enrolling by invitation
• Trial end date: 2024-07-31
• Target enrollment: 0
• Participant gender: All

Summary

Local anesthesia drugs and anesthesia technique play an imperative role in dental treatment. The purpose of this study was to compare the efficacy and safety of different dental local anesthetics drugs and brands in clinical use for the extraction of wisdom teeth.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: National Taiwan University Hospital
• Treatments: Anesthetics; Lidocaine

Criteria

Inclusion Criteria:

• Adults aged between 20-60 years old

• Generally healthy or with well-controlled mild systemic diseases (such as well-controlled hypertension, diabetes, or hyperlipidemia)

• Bilateral wisdom teeth with similar difficulty of surgery(according to Pell and Gregory and Winter's classification), which are indicated for surgical removal under local anesthesia

Exclusion Criteria:

• Known or suspected allergy to amide-type local anesthetic agents

• With systemic contraindication for tooth extraction, such as poorly-controlled heart diseases or diabetes, and severe liver or kidney diseases. Patients with systolic blood pressure greater than 150 mmHg or less than 90 mmHg or diastolic blood pressure greater than 100 mmHg or less than 60 mmHg are also excluded

• With local contraindication for tooth extraction, such as previous irradiation to the surgical region, acute infection or cellulitis at the surgical region

• Patients during pregnancy or lactation

• Patients taking analgesic or sedatives in 24 hrs

• Intolerant of dental extraction surgery under local anesthesia due to anxiety, dentophobia, or pain