Efficacy and Safety of Astragalus for Non-motor Symptoms of Parkinsonism

• Status: Recruiting
• Trial end date: 2024-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Parkinsonism is a cluster of neurodegenerative disease with motor and non-motor symptom. However, there is still a lack of research on the treatment for non-motor symptoms of Parkinsonism, especially autonomic dysfunctions such as orthostatic hypotension. Efficacy and safety of astragalus for non-motor symptoms of Parkinsonism will be assessed by an open-label self-controlled before-and-after study.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Fujian Medical University Union Hospital

Criteria

Inclusion Criteria:

• Participants with a clinical diagnosis of primary Parkinsonism and orthostatic hypotension.

• Adults signed informed consents.

Exclusion Criteria:

• Patients with history of astragalus allergy.

• Patients with secondary Parkinsonism that cannot be excluded.

• Patients with diseases that may cause other types of hypotension or similar symptoms/signs because of hypotension

• Patients with other medical conditions requiring treatments that may affect blood pressure.

• Patients with other neurological disorders.

• Patients with serious comorbidities and immune diseases.

• Uncooperative patients.

• Pregnant or lactating women.