Efficacy and Safety of Brand Versus Generic Alendronate for Osteoporosis Treatment
Status:
Completed
Trial end date:
2016-12-01
Target enrollment:
Participant gender:
Summary
Osteoporosis is a common disease defined as a decrease in bone mass and strength which
increases risk of fragility fractures. This disorder may affecting health in many adults
which causing disability, morbidity, and mortality. Current first-line medical therapy is
bisphosphonates which alendronate is one of the most widely used. However, expenditure on
medicines is one of the major problem of inadequate access to treatment.
The investigators hypothesized that generic alendronate will have the same clinical efficacy
as the brand formulation. Therefore, the result of this study is extremely crucial. If
adequate efficacy of generic alendronate could be established and if it affords the same
safety profile as those of brand alendronate, the use of generic alendronate could then be
recommended.