Efficacy and Safety of Continuous Intravenous Versus Usual Subcutaneous Insulin in Acute Ischemic Stroke

• Status: Completed
• Trial end date: 2012-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Hyperglycaemia is a frequent finding in acute ischemic stroke and associated with poor outcome. But the modalities of glucose lowering are still debated. This study will test the efficacy and safety of continuous intravenous insulin protocol versus usual subcutaneous insulin in acute ischemic stroke.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assistance Publique - Hôpitaux de Paris
• Treatments: Insulin; Insulin, Globin Zinc

Criteria

Inclusion Criteria:

• Age over 18 years

• Carotid territory stroke

• MRI performed in the first five hours of stroke onset

• Baseline National Institutes of Health Stroke Scale (NIHSS) > 4 or < 26

• Time between MRI and treatment under one hour

Exclusion Criteria:

• Pre-existing Modified Rankin Scale of three or higher

• Advanced or terminal illness with risk of death in the next 6 months, addiction