Efficacy and Safety of Cytoflavin® Used in Elderly Patients for the Prevention of Cognitive Decline After Major Surgery
Status:
Completed
Trial end date:
2019-07-11
Target enrollment:
Participant gender:
Summary
Postoperative cognitive impairment develops in the early and continues in the late
postoperative period; it is manifested by impaired memory, attention, concentration and other
higher cortical functions (thinking, speech). Early studies demonstrated the positive impact
of perioperative administration of Cytoflavin (Inosine + Nicotinamide + Riboflavin + Succinic
Acid), which prevented impairments of intelligence, speech, and attention after cardiac
surgery, both in conditions of cardiopulmonary bypass and on a working heart. The aim of the
present study is to evaluate the safety and efficacy of Cytoflavin for the prevention of
cognitive disorders after major surgeries performed in elderly patients.