Efficacy and Safety of Dexmedetomidine in the Analgesic Prophylaxis , in Patients Undergoing Cardiovascular Surgery

• Status: Recruiting
• Trial end date: 2023-10-10
• Target enrollment: 0
• Participant gender: All

Summary

Acute pain is one of the complications after cardiothoracic surgeries . It can delay patients´recovery and may increase patients´morbity and mortality. This study intends to evaluate Dexmedetomidine, a highly selective α- 2 receptor agonist, that is currently applied safely and efficiently in intraoperative cardiac surgery. It has analgesic, sedative, anxiolytic and sympatholytic properties, without respiratory- depressant effect. The aim of this study is to investigate whether the intraoperative use of dexmedetomidine is better than the standard analgesia used in the intraoperative period to reduce pain and the consequences of it.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Sao Paulo
• Collaborator: Federal University of Paraíba
• Treatments: Dexmedetomidine

Criteria

Inclusion Criteria:

• Patients at least 18 years old and who are undergoing cardiac procedures (coronary artery bypass, valve replacement or combined procedure), with cardiopulmonary by- pass.

Exclusion Criteria:

• Congenital heart disease

• Infective endocarditis

• Acute myocardial infarction (- Pregnancy

• Cancer

• Left ventricle ejection fraction < 40%

• Cardiogenic shock

• Emergent procedure

• Use of vasopressor and/or inotrope, in the preoperative

• Liver disfunction

• Renal replacement therapy

• Nephrectomy

• Previous renal transplantation

• Patients who are participating in another clinical research