Efficacy and Safety of Fruquintinib With Sintilimab as First-line Therapy in Gastric Cancer

• Status: Active, not recruiting
• Trial end date: 2025-08-31
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this clinical trial is to explore the efficacy and safety in patients with gastric adenocarcinoma or adenocarcinoma of esophagogastric junction. The main questions it aims to answer are:

• Does this therapy have a promising efficacy?

• Does this therapy have a manageable toxity? Participants will receive fruquintinib plus sintilimab as first-line therapy for gastric cancer.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: RenJi Hospital

Criteria

Inclusion Criteria:

• Histological or cytological confirmed advanced, recurrent, of metastasic gastric adenocarcinoma or adenocarcinoma of esophagogastric junction;

• ECOG PS: 0-2;

• Adequate hepatic, renal, heart, and hematologic functions;

• At least one measurable lesion (according to RECIST1.1);

• Haven't received any systematic treatment for the cancer involved;

• Expected survival > 12 weeks;

• Contraception until 6 months after the study termination;

• Signed informed consent.

Exclusion Criteria:

• Her-2-positive gastric cancer, or exposed to any immune checkpoint inhibitor;

• Participated in another study;

• Immunodeficiency;

• Received allograft；

• Unmanagerable hypertension, diabetes, or coronary disease;

• Have difficulty in taking medicine, or active bleeding;

• Pulmonary tuberculosis, or interstitial lung disease that needs steroid therapy;

• Infection of HIV, HBV, HCV, or other unmanageable infection;

• Other malignant tumor history;

• Allergic to the test drug;

• Other diseases which will affect the results of this study;

• Received resection of stomach;

• Taking anti-tumor traditional Chinese Medicine;

• Severe active bleeding.