Overview

Efficacy and Safety of Individualized P2Y12 Receptor Antagonists Treatment Based on Agregometry Versus Fixed Dose Regimen in Patients After Acute Myocardial Infarction

Status:
Completed

Trial end date:
2019-12-01

Target enrollment:

Participant gender:

Summary

The specific goal of this study is to determine whether the individualized approach and adjusting the dosage of the P2Y12 receptor inhibitors will improve the platelet inhibiton and the clinical outcome in patients with an ACS, that were treated with PCI and the aforementioned drugs, but with an increased initial residual platelet activity. It is expected that the patients that have undergone the P2Y12 inhibitor therapy adjustment (according to the platelet reactivity measured by POC devices) will have better clinical outcomes (ie less ischemic events, without a significant increase in bleeding events) than those who did not undergo the therapy adjustment.

Phase:

Phase 4

Details

Lead Sponsor:

University of Zagreb

Collaborators:

Clinical Hospital Centre Zagreb
Croatian Science Foundation

Treatments:

Clopidogrel
Ticagrelor