Efficacy and Safety of Ivermectin and Doxycycline in Combination or IVE Alone in Patients With COVID-19 Infection.
Status:
Completed
Trial end date:
2020-11-20
Target enrollment:
Participant gender:
Summary
Burden:
Initial outbreak of corona virus disease 2019 (COVID-19) was reported from Wuhan, China in
early December 2019.Presently known to be caused by a novel beta-corona virus, named as
Severe acute respiratory syndrome corona virus 2 ( SARS-CoV-2).
World Health Organization (WHO) declared a pandemic on March.
The clinical characteristics of COVID-19 include respiratory symptoms, fever, cough, dyspnoea
and pneumonia
Infected individuals exhibit:
1. Mostly mild illness (80% +) recover without any treatment (~80%)
2. Moderate illness that needs hospitalization and recovers after standard
3. supportive treatment (~14%)
4. Critical illness (~5%) needs ICU support
5. Death (1-2% )
COVID-19 has now spread >210 countries and territories globally. SARS-CoV-2 is a respiratory
virus which spreads primarily through droplets generalized when an infected person coughs or
sneezes or through droplets of saliva or discharge from the nose.
Symptomatic management remains the mainstay of treatment strategy. Mortality appears to be
more common in older individuals and those with co-morbidities, such as chronic lung disease,
cardiovascular disease and diabetes. Young people with no comorbidities also appear to be at
risk for critical illness including multi-organ failure and death. Seen more in Bangladesh
between 21-40 yrs of age.
Knowledge Gap:
There is no specific treatment against this new virus that WHO has officially declared until
now.There are many pharmacologic therapies that are being used or considered for treatment of
COVID-19. National Guidelines on Clinical Management of Corona virus Disease 2019 (Covid-19):
V 5.0 date 9th April 2020) CDC, DGHS, GoB
Thus an RCT is urgently needed in Bangladesh: Based on recent literatures on Rx studies in
COVID-19 patients from other countries as well as its availability & affordability of those
repurposed medicines
Phase:
Phase 2
Details
Lead Sponsor:
International Centre for Diarrhoeal Disease Research, Bangladesh