Overview

Efficacy and Safety of L-asparaginase Encapsulated in RBC Combined With Gemcitabine or FOLFOX in 2nd Line for Progressive Metastatic Pancreatic Carcinoma

Status:
Completed

Trial end date:
2017-11-01

Target enrollment:

Participant gender:

Summary

A new approach that aims to destroy pancreatic tumor cells through modification of the tumor environment. Asparagine synthetase (ASNS) is an enzyme wich synthetise asparagine. Asparagine is an essential nutriment for pancreatic cancer cells which have no or low level of ASNS. by L-asparaginase encapsulated in erythrocytes deplete (supress) Plasma asparagine. in selected patients having no or low ASNS, may provide a new therapeutic approach.

Phase:

Phase 2

Details

Lead Sponsor:

ERYtech Pharma

Treatments:

Asparaginase
Fluorouracil
Gemcitabine
Leucovorin
Oxaliplatin