Efficacy and Safety of Levamisole Combined With Standard Prednisolone in Warm Antibody Autoimmune Hemolytic Anemia.

• Status: Unknown status
• Trial end date: 2016-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether Levamisole plus prednisone can further improve the efficacy，extend the remission duration and reduce the dosage of prednisone for newly diagnosed warm antibody autoimmune hemolytic anemia.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Institute of Hematology & Blood Diseases Hospital
• Treatments: Antibodies; Autoantibodies; Immunoglobulins; Levamisole; Methylprednisolone; Methylprednisolone acetate; Methylprednisolone Hemisuccinate; Prednisolone; Prednisolone acetate; Prednisolone hemisuccinate; Prednisolone phosphate; Prednisone

Criteria

Inclusion Criteria:

• Clinical and biochemical signs of hemolytic anaemia

• Positive Coombs test with anti-IgG or and with anti-CD3d

• Newly diagnosed Warm Autoimmune Hemolytic Anemia

• Adequate contraceptive measures for women of childbearing potential

• informed consent signed

Exclusion Criteria:

• Active infection which requires antibiotic treatment

• Pregnant or lactating women

• Epilepsy and mental illness

• Kidney and liver function abnormal