Efficacy and Safety of Lisdexamfetamine Dimesylate in Adults With Chronic Fatigue Syndrome
Status:
Completed
Trial end date:
2011-03-01
Target enrollment:
Participant gender:
Summary
Over the past decade, the Rochester Center for Behavioral Medicine (RCBM) has evaluated many
patients with attention deficit hyperactivity disorder (ADHD). A recurrent finding in these
patients is a history of unexplained fatigue and musculoskeletal pain.
Treatment of these patients in our clinic has revealed that when their underlying ADHD is
treated with psychostimulant medication, many patients report significant improvements with
regard to their fatigue and musculoskeletal pain. Patients report less subjective fatigue and
pain and note overall functional improvement, although the initial and primary objective was
the treatment of their attention or hyperactivity problems. We speculate that stimulants are
efficacious by offering two distinct clinical properties. 1) anti-fatigue properties and 2)
properties that allow patients to filter out extraneous stimuli (i.e. chronic muscle pain).