Efficacy and Safety of Minodronate in Patients With Low Back Pain

• Status: Not yet recruiting
• Trial end date: 2024-04-01
• Target enrollment: 0
• Participant gender: Female

Summary

This study will provide objective evidence for the efficiency and safety of minodronate in the treatment of postmenopausal osteoporosis with low back pain protocol. Furthermore, it will be helpful to evaluate the quantitative relationship between bone metabolic markers (BTM) and bone mineral density (BMD) in patients with osteoporosis under different ages.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Peking University Third Hospital
• Treatments: Alendronate

Criteria

Inclusion Criteria:

1. Chinese postmenopausal patients with a diagnosis of OP;

2. Patients with low back pain of at least 3 months and a VAS score ≥30;

3. The value of lumbar L1-4 or total hip bone density measured by DXA is < -2.5;

4. Serum 25-hydroxyvitamin D (25-OHD) concentration ≥20 ng/mL;

5. Patients with full capacity for civil conduct and understanding of the research process and methods voluntarily participated in this study and signed the informed consent form.

Exclusion Criteria:

1. Patient who are allergic to minodronate, alendronate, or other bisphosphonate drug or any other component of the drug under evaluation;

2. Patients with a diagnosis of secondary OP;

3. The following drugs affecting bone metabolism were used before the screening:

Received injections of bisphosphonate and denosumab within 3 years; Received oral bisphosphonate, parathyroid hormones or analogues, strontium, or fluoride within 6 months; Received glucocorticoids, steroids, immunosuppressants, calcitonin, calcitriol or its analogues, thiazide diuretics, and ng-acting oestrogen/progesterone replacement therapy within 3 months;

4. Patients with a diagnosis of diseases affecting bone metabolism (e.g., osteogenesis imperfecta, malignancy, progressive diaphyseal dysplasia, Paget's disease, rheumatoid arthritis, osteosclerosis, osteoporosis with a slipped disc and spinal stenosis, and liver and kidney failure);

5. Patients are participating or have participated in an investigational drug study within 3 months before signing the informed consent form;

6. Patients under 75 years old with a creatinine clearance rate < 60 mL/min and those > 75 years old with a creatinine clearance rate < 45 mL/min;

7. Serum calcium levels < 2.0 mmol/L (8 mg/dL) or > 2.7 mmol/L (11.0 mg/dL);

8. Patients with fever, severe infection, severe trauma, or major surgery within 30 days;

9. Patients with a QTc interval of > 480 ms;

10. Patients are undergoing or planning to undergo invasive dental treatment;

11. Smoking history in the past six months;

12. Patients with a history of alcohol abuse (> 15 g of alcohol per day, equivalent to 350 mL of beer or 150 mL of wine, more than twice per week) and drug abuse;

13. Patients with a prior history of cerebral infarction, ischaemic or haemorrhagic stroke;

14. Patients with implants and/or fractures in the lumbar spine or hip that interfere with BMD testing;

15. Received pain relievers (e.g., nonsteroidal anti-inflammatory drugs, central analgesics) or life interventions to relieve pain within 1 week before screening;