Efficacy and Safety of Modified Gegen Qinlian Decoction for Ulcerative Colitis With Damp-heat Syndrome
Status:
Recruiting
Trial end date:
2023-12-31
Target enrollment:
Participant gender:
Summary
Ulcerative colitis(UC) seriously affect the quality of life in patients. Clinically, it is
effective to apply therapeutic method of clearing heat and promoting diuresis to the common
syndrome of dampness-heat. Dysbiosis of intestinal microbiota is closely related to the
immune imbalance and intestinal mucosal barrier injury. C1orf106/CYTH-1/ARF6 signal pathway,
which derive from intestinal micro environment changes,is the mainly cause of intestinal
mucosal barrier injury, and this is may be the common pathogenesis of dampness-heat syndrome
in UC . Based on the clinic, the project is to study the effect and mechanism of Chinese
compound formula of clearing heat and promoting dieresis in modulating intestinal microbiota
dysbiosis, repairing intestinal mucosal barrier and reconstructing intestinal
microenvironment. With the combination of metagenomics and metabonomics, the study compare
the differences of co-metabolites of intestinal microbiota and host within the healthy
people, UC patients with dampness-heat syndrome, to explore the relevance between intestinal
flora and host co-metabolites. Furthermore, the experimental study is to clarify the drug
targets via C1orf106/ CYTH-1/ARF6 signal pathway.Through the study of association between
dampness-heat syndrome in UC and intestinal microbiota, it is of important academic
significance to reveal the Chinese theory intension of "homotherapy for heteropathy ".
Phase:
Early Phase 1
Details
Lead Sponsor:
Xiyuan Hospital of China Academy of Chinese Medical Sciences