Efficacy and Safety of Pactimibe in Patients With Atherosclerosis

• Status: Completed
• Trial end date: 2005-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The effect of pactimibe on the reduction of atherosclerosis in the carotid artery will be assessed using carotid ultrasound

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sankyo Pharma Gmbh

Criteria

Inclusion Criteria:

• Increased cardiovascular risk (i.e. history of myocardial infarction, stroke, diabetes mellitus, left ventricular hypertrophy)

• Intima-media thickness greater than or equal to 0.8 mm as measured by ultrasonography

• Negative pregnancy test for females

Exclusion Criteria:

• Whole blood donation (greater than or equal to 450 ml) during the last three months before study start

• Unstable angina, congestive heart failure or uncontrolled hypertension

• Renal disease including nephrectomy and/or renal transplant

• Hepatic disease or abnormal liver function parameters

• Drug abuse or alcohol addiction