Efficacy and Safety of Polidocanol Foam 3% in the Treatment of II Degree Hemorrhoidal Disease
Status:
Completed
Trial end date:
2020-06-02
Target enrollment:
Participant gender:
Summary
Hemorrhoidal disease (HD) is one of the oldest and most common proctologic diseases that has
been described with an estimated prevalence between 4.4% and 86%. Despite the proposal of
three mechanisms that might underlie haemorrhoidal development - the varicose vein theory,
the vascular hyperplasia theory and the sliding anal-lining theory, the exact pathophysiology
of symptomatic hemorrhoid disease is poorly understood.
HD seems to be the most common cause for rectal bleeding, or hematochezia, and the second
most frequent cause for severe rectorrhagia after diverticulitis. The blood is bright red and
coats the stool at the end of defection. Other symptoms include pain, mucous discharge,
itching or the sensation of tissue prolapse.
The most widely accepted classification is the Goligher classification:
- Grade I: hemorrhoids bleed but do not prolapse out of the anal canal;
- Grade II: hemorrhoidal cushions prolapse outside of the anal canal on straining or
during bowel movements, but reduce spontaneously;
- Grade III: hemorrhoidal cushions prolapse outside the anal canal on straining and
require manual reduction;
- Grade IV: hemorrhoidal prolapse is irreducible even with manipulation