Efficacy and Safety of Sertraline in the Treatment of Maintenance Hemodialysis Patients With Depression

• Status: Completed
• Trial end date: 2023-09-29
• Target enrollment: 0
• Participant gender: All

Summary

Depression is a common mental disorder in patients undergoing maintenance hemodialysis (MHD), which increases the risk of cardiovascular events, hospitalization rates, and mortality, but has not received enough attention from patients and medical staff. Sertraline is a selective serotonin reuptake inhibitor with fewer adverse reactions and higher safety compared to other antidepressants. This study aims to investigate the efficacy and safety of sertraline in patients undergoing MHD with depression.

This study used a randomized controlled design and evaluated the depression status of the patients using the Hamilton Depression Scale (HAMD). MHD patients with comorbid depression were recruited and divided into the treatment group and the control group. The treatment group received sertraline for antidepressant therapy, while the control group did not receive any antidepressant medication. To investigate the efficacy and safety of sertraline before and after intervention.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: First Affiliated Hospital of Chongqing Medical University
• Treatments: Sertraline

Criteria

Inclusion Criteria:

1. Long-term MHD patients in the blood purification center of our hospital, older than 18 years old, maintenance dialysis for at least 3 months, 2-3 times a week, 3-4.5 hours each time;

2. Meet the CKD5 diagnostic criteria;

3. The cardiopulmonary function was relatively stable before enrollment, and the life expectancy was more than 1 year;

4. The clinical data were basically complete;

5. Consciousness, intelligence is normal, can understand the questionnaire content.

Exclusion Criteria:

1. Communication, communication disorders or other psychiatric history;

2. Combined with active pulmonary tuberculosis, AIDS, severe infection patients;

3. Pregnant or lactating women;

4. Those who are taking antidepressants or other antipsychotic drugs;

5. Unable or unwilling to cooperate with the researcher.