Efficacy and Safety of Topical Diclofenac Combined With Oral Diclofenac in the Treatment of Knee Osteoarthritis
Status:
Completed
Trial end date:
2005-09-01
Target enrollment:
Participant gender:
Summary
Oral non-steroidal anti-inflammatory drugs (NSAIDs) are a recommended treatment for the
symptoms of osteoarthritis of the knee. However, NSAIDs may cause a range of negative side
effects, including stomach pain, heartburn, bleeding stomach ulcer, and liver or kidney
abnormality. A topical NSAID may relieve pain and other symptoms of osteoarthritis of the
knee, while minimizing the side effects common to oral NSAIDs. The purpose of this study is
to determine the safety and effectiveness of a topical NSAID when used alone or when combined
with an oral NSAID in the treatment of osteoarthritis of the knee.