Efficacy and Safety of Total Glucosides of Paeony Combined With NB-UVB on Treating Vitiligo
Status:
Completed
Trial end date:
2019-07-31
Target enrollment:
Participant gender:
Summary
1. Total Glucosides of Paeony(TGP) As a traditional Chinese medicine, peony root is the
dried root of peony of Ranunculaceae, cultivated all over the country.The main
ingredient is a group of glycosides, including paeoniflorin, hydroxy paeoniflorin,
paeoniflorin, paeoniflorin, benzoyl paeoniflorin etc, collectively referred to as total
glucosides of paeony（TGP）. Paeoniflorin accounted for more than 90% of the TGP, is the
main active ingredient of white peony root.By pharmacological and clinical studies of
TGP, it have found that the mechanism of TGP is unique and mainly acts on the upstream
of the immune response - inhibiting the presentation of antigens. It is different from
immunosuppressive agents on T, B lymphocytes, or hormones and other drugs acting on the
whole process.
2. Vitiligo Vitiligo is a pigment deprived skin disease caused by the destruction of
melanocytes, the global incidence of about 1%. The pathogenesis is not yet clear, the
current study shows that oxidative stress and autoimmunity is an important part of its
occurrence and development.
3. The basic and clinical research of TGP used in vitiligo The ratio of cluster of
differentiation 4+ / cluster designation 8+ T cell vs. cluster of differentiation 4+
chronotropic dose 25+ in the peripheral blood of patients with vitiligo could be
significantly increase, after patients treatment by TGP combined with tacrolimus.
Thereby enhancing the patient's maintenance of immune self-stability and Immune
tolerance ability, promoting the healing of skin lesions. It showed significant effect
in stable vitiligo,when patients treated by autologous epidermal grafting combined with
TGP.
Phase:
N/A
Details
Lead Sponsor:
xjpfW
Collaborators:
Air Force General Hospital of the PLA Chinese Academy of Medical Sciences First Hospital of China Medical University