Efficacy and Safety of Two Treatment Algorithms in Adults With Moderate to Severe Crohn's Disease
Status:
Completed
Trial end date:
2017-01-03
Target enrollment:
Participant gender:
Summary
The primary objective of this study was to demonstrate that tight control of disease
activity, using stringent criteria based on Crohn's disease activity Index (CDAI), biomarkers
(high sensitivity C-reactive protein [hs-CRP] and fecal calprotectin), and corticosteroid
use, improves the rate of mucosal healing 48 weeks after randomization compared with
management using less stringent criteria based only on CDAI and corticosteroid use.