Overview
Efficacy and Safety of a Preparation Containing an Antibiotic and Anti-Inflammatory Agent in Acne Vulgaris
Status:
Completed
Completed
Trial end date:
2006-01-01
2006-01-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
The concept behind our study was to combine an effect of antibiotic and anti-inflammatory agents for a more efficient acne therapy directed at the factors involved in the pathophysiology of the disease. For this purpose we evaluated a combination of clindamycin phosphate and salicylic acid in a non-irritating carrier.Phase:
Phase 1/Phase 2Details
Lead Sponsor:
Hadassah Medical OrganizationTreatments:
Anti-Inflammatory AgentsClindamycin
Clindamycin palmitate
Clindamycin phosphate
Salicylates
Salicylic Acid
Criteria
Inclusion Criteria:- mild to moderate acne vulgaris;
- at least 5 lesions on the face;
- a one-month wash-out period was established for any topical or systemic drug use for
treatment of acne vulgaris.
Exclusion Criteria:
- acne that was primarily truncal, nodular, or due to secondary causes/internal disease;
- pregnancy, breastfeeding, or intention to become pregnant;
- another dermatological disease of the face;
- significant systemic disease;
- any drug/alcohol addiction;
- interacting medication;
- known hypersensitivity to study medications;
- history of chronic disease treated with medications which might affect acne condition
and treatment outcome (e.g. corticosteroids, lithium, isoniazid, anti-androgens,
phenytoin, phenobarbital) in the preceding month