Overview

Efficacy and Safety of a Preparation Containing an Antibiotic and Anti-Inflammatory Agent in Acne Vulgaris

Status:
Completed
Trial end date:
2006-01-01
Target enrollment:
0
Participant gender:
All
Summary
The concept behind our study was to combine an effect of antibiotic and anti-inflammatory agents for a more efficient acne therapy directed at the factors involved in the pathophysiology of the disease. For this purpose we evaluated a combination of clindamycin phosphate and salicylic acid in a non-irritating carrier.
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
Hadassah Medical Organization
Treatments:
Anti-Inflammatory Agents
Clindamycin
Clindamycin palmitate
Clindamycin phosphate
Salicylates
Salicylic Acid
Criteria
Inclusion Criteria:

- mild to moderate acne vulgaris;

- at least 5 lesions on the face;

- a one-month wash-out period was established for any topical or systemic drug use for
treatment of acne vulgaris.

Exclusion Criteria:

- acne that was primarily truncal, nodular, or due to secondary causes/internal disease;

- pregnancy, breastfeeding, or intention to become pregnant;

- another dermatological disease of the face;

- significant systemic disease;

- any drug/alcohol addiction;

- interacting medication;

- known hypersensitivity to study medications;

- history of chronic disease treated with medications which might affect acne condition
and treatment outcome (e.g. corticosteroids, lithium, isoniazid, anti-androgens,
phenytoin, phenobarbital) in the preceding month