Efficacy and Tolerance of a Derivative of Salicylic Acid and 5% Benzoyl Peroxide in Facial Acne Vulgaris
Status:
Completed
Trial end date:
2006-08-01
Target enrollment:
Participant gender:
Summary
Acne vulgaris is a frequent inflammatory skin condition involving the pilosebaceous unit and
affecting more than 80% of teenagers. Mild to moderate acne vulgaris is usually treated with
topical agents such as benzoyl peroxide, retinoids and antibiotics. These treatments can be
associated with local tolerance problems and/or antibiotic resistance. Salicylic acid has
been shown to be an effective treatment for acne. LHA is a lipophilic hydroxy acid derivative
of salicylic acid that has comedolytic and antibacterial properties.
The objective of this trial was to compare the efficacy and tolerance of a cream formulation
containing 0.3% LHA (LHA formulation) to a 5% benzoyl peroxide gel.