Efficacy of 3% Hypertonic Saline in Acute Viral Bronchiolitis

• Status: Completed
• Trial end date: 2014-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether nebulized hypertonic saline solution reduces the admission rate 48 hours after initial treatment in the emergency department, when compared to normal saline solution (control).

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assistance Publique - Hôpitaux de Paris
• Treatments: Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• Age 6 weeks through 12 months

• First moderate to severe episode of acute viral bronchiolitis (history of viral upper respiratory tract infection plus wheezing and/or crackles on chest auscultation with respiratory distress ).

• Admission in Emergency Department

• Parental/guardian permission (informed consent)

Exclusion Criteria:

• prematurity < 37 weeks

• artificial ventilation in the neonatal period

• Chronic lung or heart disease

• history of immunodeficiency

• past use of nebulized HS

• initial need for intensive care of assisted ventilation

• Non-French speaking parent/guardian