Efficacy of AFL-assisted PDT With Short Incubation Time in Actinic Keratosis

• Status: Completed
• Trial end date: 2014-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Photodynamic therapy (PDT) using methyl aminolevulinate (MAL) is an effective first-line treatment for actinic keratosis (AK). Erbium: yttrium-aluminium-garnet (Er:YAG) ablative fractional laser-assisted MAL-PDT (AFL-PDT) has shown significant benefit for the treatment of AK. However, knowledge on the optimal photosensitizer incubation time for AFL-PDT is limited

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Dong-A University

Criteria

Inclusion Criteria:

• age >18 years

• the presence of 2-10 facial AK lesions

Exclusion Criteria:

• lactating or pregnant women

• patients with porphyria

• a known allergy to any of the constituents of the MAL cream and lidocaine

• patients with systemic disease

• history of malignant melanoma

• tendency for melasma development or keloid formation

• any AK treatment of the area in the previous 4 weeks

• any conditions associated with a risk of poor protocol compliance

• patients on immunosuppressive treatment