Efficacy of Acetaminophen in Posterior Fossa Surgery
Status:
Withdrawn
Trial end date:
2018-10-01
Target enrollment:
Participant gender:
Summary
Uncontrolled pain after posterior fossa surgery and associated negative side effects of
conventional opioid therapy causes significant morbidity and mortality in infants and
children. Intravenous (IV) acetaminophen has been shown to be effective in treating mild to
moderate pain, and moderate to severe pain in conjunction with adjuvant opioids in children.
However, it is unknown if IV acetaminophen is effective as analgesic adjuvant therapy in
children undergoing posterior fossa surgery. In this prospective, randomized controlled
trial, the investigators aim to determine whether the addition of IV acetaminophen for 24
hours can lead to reduction in postoperative pain and opioid requirement after neurosurgical
procedures of the posterior fossa compared with conventional therapy.
Phase:
Phase 2
Details
Lead Sponsor:
Children's National Research Institute Srijaya K. Reddy, MD, MBA