Efficacy of Aerobic Exercise Added to Alprazolam in Panic Disorder Treatment

• Status: Completed
• Trial end date: 2009-09-30
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether the combination of aerobic physical exercise and alprazolam in patients with panic disorder has a better therapeutic response than the treatment with alprazolam alone.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Buenos Aires
• Treatments: Alprazolam

Criteria

Inclusion Criteria:

• Patients with panic disorder scored between 20 and 30 by the Hamilton Anxiety Rating Scale/14. (Baseline scale scores were measured during the first interview and diagnoses were made by a psychiatrist using the Structured Clinical Interview for DSM IV).

• Good physical health and normal results determined on a previous physical examination and routine laboratory tests (renal, hepatic, hematological and thyroid function).

• Patients who completed a written informed consent form (which was obtained from every included patient and had been fully explained before the procedure).

Exclusion Criteria:

• A history of some kind of recent somatic disease.

• Diagnosis of some other type of associated or psychiatric disease of axis I of DSM IV, such as affective disorders, drug dependency.

• Hamilton Anxiety Scale lower than 20 points or higher than 30.

• Use of some other type of medication or treatment (including psychotherapy) or having received it during last past 3 months.

• Patients who could not complete the clinical examination

• Patients who have not accepted to complete or sign the written informed consent.

• Pregnant patients or in lactation. (A pregnancy test was performed for women in fertile age)

• Patients with history of rejection to the used drug.