Efficacy of Amoxicillin-Esomeprazole HDDT Compared to Levofloxacin Triple Therapy for H. Pylori Eradication: A RCT
Status:
Recruiting
Trial end date:
2024-02-01
Target enrollment:
Participant gender:
Summary
The goal of this clinical trial is to compare the efficacy of two different therapeutic
regimen for the treatment of Helicobacter pylori infected dyspeptic patients. The aim is -
1. To identify the percentage of H. pylori infection among dyspeptic patients
2. To compare the efficacy of amoxicillin-esomeprazole high dose dual therapy with
levofloxacin containing triple therapy for the eradication of Helicobacter pylori.
Participants will be screened on the basis of two different test (stool antigen test &
endoscopy with rapid urease test) to detect H. pylori infection. Who are positive on both
tests will be finally enrolled in the study and randomized into two groups . one group will
receive amoxicillin & esomeprazole for 14 days in higher dose. The other group will receive
amoxicillin, levofloxacin & esomeprazole for 14 days in usual dose.
Dyspeptic symptoms will be recorded before & after treatment. Side effects of drugs will also
be recorded. Finally 1 month after completion of treatment , H.pylori status will be cheeked
by stool antigen test and results will be compared between two groups.
Phase:
Phase 4
Details
Lead Sponsor:
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh