Efficacy of Antioxidant Therapy Compared With Enalapril in Sickle Nephropathy

• Status: Unknown status
• Trial end date: 2015-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether enalapril or antioxidant therapy (N-Acetylcysteine) is effective in reducing microalbuminuria in children with sickle cell disease and and its progression to sickle nephropathy

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The University of The West Indies
• Collaborator: Caribbean Health Research Council
• Treatments: Acetylcysteine; Antioxidants; Enalapril; Enalaprilat; N-monoacetylcystine

Criteria

Inclusion Criteria:

• Homozygous S sickle cell disease

• Diagnosed by newborn screening

• determined to have persistent microalbuminuria

• satisfied criteria for microalbuminuria screening

• parental consent

Exclusion Criteria:

• Asymptomatic bacteriuria on screening urine cultures

• On Hydroxyurea therapy

• Pre-existing complications of SCD which would meet local criteria for HU therapy