Efficacy of Azithromycin as an Adjunct to Non-Surgical Periodontal Treatment
Status:
Completed
Trial end date:
2016-10-30
Target enrollment:
Participant gender:
Summary
This study evaluates the effect of the systemic administration of azithromycin as a therapy
associated with non-surgical periodontal treatment, in the clinical and microbiological
variables of patients with Severe Periodontitis with moderate rate of progression (Stage III
grade B). A double-blind, randomized, controlled trial was conducted with 18 voluntary
patients with a history of moderate to severe chronic periodontitis, who met the inclusion
and exclusion criteria and signed an informed consent.
The intervention group received Scaling and Root Planning (SRP) plus azithromycin, and the
control group received SRP plus placebo. Probing Pocket Depth (PPD) Clinical Attachment Level
(CAL), Plaque Index (PI) and Bleeding on Probing (BoP) were evaluated as clinical variables
while Porphyromonas gingivalis (Pg), Tannerella forsythia (Tf), Treponema denticola (Td),
Fusobacterium nucleatum (Fn) were the microbiological variables detected by conventional
Polymerase chain reaction (PCR).