Efficacy of Baclofen in the Treatment of Alcohol Addiction
Status:
Completed
Trial end date:
2006-11-01
Target enrollment:
Participant gender:
Summary
Intervention to achieve alcohol abstinence represents the most effective treatment for
alcoholic patients with liver cirrhosis. However no trials have evaluated the efficacy of
anti-craving drugs in these patients because of the concern that these medications might
worsen liver disease. Baclofen is effective to reduce alcohol craving improving abstinence in
alcohol-dependent patients. It is mainly eliminated by kidney. No hepatic side-effects have
been reported in treated patients. The present study investigates the efficacy and safety of
baclofen in achieving and maintaining abstinence in alcoholic cirrhotic patients.