Efficacy of Block Injection of an Anti Inflammatory Medicine in Patients With Mandibular Dental Pain

• Status: Completed
• Trial end date: 2018-11-15
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to determine whether inferior alveolar nerve block of ketorolac and lidocaine would improve the success rate in teeth with symptomatic irreversible Pulpitis.

Design: In this randomized double-blind clinical trial, sixty healthy adult volunteers with including criteria have been randomly divided into two groups (n=30). Following the 5 minutes of the first IANB using 1.8 ml 2% lidocaine 2% containing 1:100000, the patients of case group have received a standard inferior alveolar nerve block injection that used 1 ml ketorolac tromethamine 30 mg/ml. The patients of the control group received a sham injection. After achieving the lip numbness, access preparation initiated after 15 minutes of initial IANB with two negative responses to the electric pulp test. Any pain during caries and dentin removal, access cavity preparation, and root canal preparation have been recorded using analog visual scale (HP-VAS). The success was considered as none or mild pain during treatment. The data have been analyzed using Mann-U-Whitney test.

Intervention main outcome measures: Pain during caries and dentin removal access cavity preparation, and root canal preparation using VAS.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Azad University of Medical Sciences
• Treatments: Ketorolac; Ketorolac Tromethamine

Criteria

Inclusion Criteria:

• patients with age ranged 18-65

• without systemic diseases;

• without any medicine consumption;

• nonsmoking;

• nonpregnant;

• non-breastfeeding;

• with symptomatic irreversible pulpitis (Visual Analog Scale ≥ 54) in one mandibular

• the molar that needs root canal treatment

Exclusion Criteria:

• patients under 18 or above 65 years old

• with systemic diseases;

• with any medicine consumption;

• smoking;

• pregnant;

• breastfeeding;

• without symptomatic irreversible pulpitis (Visual Analog Scale ≥ 54) in one mandibular

• the molar that needs root canal treatment